TABLE 1.
HdAg reduces the severity of DSS-induced colitis after 5 days of treatment
| Exptl groupa | Result for parameterb: |
||
|---|---|---|---|
| Colon length (cm) | DAS | Histopathology score | |
| Water | 8.6 ± 0.1 | 0 | 0 |
| HdAg | 8.4 ± 0.3 | 0.2 ± 0.2 | 0 |
| DSS | 7.2 ± 0.2* | 1.6 ± 0.4* | 3.0 ± 0.8* |
| DSS+HdAg | 8.2 ± 0.3# | 0.5 ± 0.2# | 1.0 ± 0.3*# |
a
DSS, dextran sodium sulfate at 5% (wt/vol) for 5 days; HdAg, PBS-soluble H. diminuta antigens at 1 mg i.p. on alternate days.
b
DAS, disease activity score. Data are means ± SEM from 2 experiments (n = 7 mice). * and #, P < 0.05 compared to the groups treated with water only and DSS, respectively.