TABLE 2.

HdAg regulation of mitogen-stimulated cytokine production by splenocytes

Cytokine	Cytokine production (pg/ml) in exptl groupa:
	DSS (5% [wt/vol])	DSS+HdAg
		100 μg	500 μg	1 mg
IFN-γ	2,376 ± 492	1,113 ± 179*	1,091 ± 187*	691 ± 80*
IL-17	17,867 ± 275	911 ± 191*	401 ± 80*	322 ± 35*
TNF-α	178 ± 18	113 ± 25	47 ± 9*	58 ± 14*
IL-4	48 ± 3	52 ± 7	89 ± 15*	112 ± 17*

^aDSS, dextran sodium sulfate at 5% (wt/vol) for 5 days; HdAg, PBS-soluble H. diminuta antigens given at 100 μg, 500 μg, or 1 mg i.p. on alternate days. Data are means ± SEM from 2 experiments (n = 7 mice). *, P < 0.05 compared to the DSS-treated group.