FIG 1.

Schematic representations of PadA, Hsa, LysA2, and the chimeric proteins Hsa-LysA2 and PadA-LysA2. PadA is composed of a leader peptide (in black), a unique N-terminal region (in gray) which comprises a von Willebrand factor-A1-like domain, 14 repeat blocks with unknown function (in white), and a C-terminal cell wall anchoring domain (with diagonal lines). The primary sequence of Hsa comprises a leader peptide (in black), two serine-rich regions (in white), one located in the N-terminal region and the other in the C-terminal region (in gray), and a C-terminal cell wall-anchoring domain (with diagonal lines). LysA2 contains an N-terminal catalytic domain (with vertical lines) and a C-terminal cell wall binding domain (in light gray). Molecular weights at right are in thousands.