FIG 2.

InlP is a virulence determinant in mice. Shown are data for intravenous infection of nonpregnant (A to C) and pregnant (D to F) mice with the wild-type (black circles) or ΔinlP (empty squares) strain. (A to C) CFU per gram in spleen (A), liver (B), and uterus (C) 24 and 72 h p.i. with 7 × 10⁴ CFU. (D to F) CFU per gram in spleen (D), liver (E), and (F) placenta 48 h p.i. with 10⁴ CFU or 5 × 10⁴ CFU. Total numbers of placentas were 36 for wild-type and 25 for ΔinlP mutant infection with an inoculum of 10⁴ CFU and 62 for wild-type and 66 for ΔinlP mutant infection with an inoculum of 5 × 10⁴ CFU. Mann-Whitney U test was used for statistical analysis (*, P < 0.05; **, P < 0.005; ****, P < 0.0001). Horizontal bars indicate medians, and horizontal dashed lines indicate the detection limit.