Table 3. Multivariate Logistic Regression Analysis of IHC Subtypes for Clinical and Radiologic Factors Compared to the Luminal A Subtype After Adjustment for Histologic Grade.
Variable | Luminal B (n = 54) | HER2+ (n = 35) | TN (n = 34) | |||
---|---|---|---|---|---|---|
OR (95% CI) | P Value | OR (95% CI) | P Value | OR (95% CI) | P Value | |
Age | 0.981 (0.947 - 1.015) | 0.268 | 1.029 (0.987 - 1.072) | 0.178 | 0.973 (0.929 1.019) | 0.245 |
Symptoms | ||||||
No | 1.0 | 1.0 | 1.0 | |||
Yes | 0.531 (0.255 - 1.106) | 0.091 | 1.099 (0.449 - 2.691) | 0.836 | 0.856 (0.315 - 2.323) | 0.761 |
MMG finding | ||||||
Negative | 1.0 | 1.0 | 1.0 | |||
Asymmetry/mass | > 999.999 (< 0.001 -> 999.999) | 0.951 | > 999.999 (< 0.001 - > 999.999) | 0.962 | 0.364 (0.049 - 2.734) | 0.407 |
Mass with calcification | > 999.999 (< 0.001 - >999.999) | 0.948 | > 999.999 (< 0.001- > 999.999) | 0.958 | 0.285 (0.027 - 2.983) | 0.295 |
US BI-RADS | ||||||
4a | 1.0 | 1.0 | 1.0 | |||
4b | 0.427 (0.075 - 2.417) | 0.336 | 9.005 (1.414 - 57.348) | 0.020 | 2.027 (0.329 - 12.475) | 0.446 |
> 4c | 1.284 (0.538 - 3.065) | 0.573 | 4.669 (0.970 - 22.468) | 0.055 | 1.398 (0.402 - 4.865) | 0.598 |
Cancer type | ||||||
IDC | 1.0 | 1.0 | 1.0 | |||
Mucinous | 1.200 (0.189 - 7.638) | 0.847 | 3.000 (0.218 - 41.351) | 0.412 | < 0.001 (< 0.001 - > 999.999) | 0.956 |
Medullary | > 999.999 (< 0.001 - > 999.999) | 0.970 | 0.515 (< 0.001 - > 999.999) | 0.999 | < 0.001 (< 0.001 - > 999.999) | 0.967 |
Papillary | < 0.001 (< 0.001 - > 999.999) | 0.978 | < 0.001 (< 0.001 - > 999.999) | 0.982 | < 0.001 (< 0.001 - > 999.999) | 0.984 |
T-stage | ||||||
T1 | 1.0 | 1.0 | 1.0 | |||
T2 | 1.226 (0.579 - 2.597) | 0.595 | 3.173 (1.248 - 8.066) | 0.015 | 2.376 (0.876 - 6.446) | 0.089 |
T3 | 0.469 (0.046 - 4.783) | 0.523 | 6.552 (1.252 - 34.296) | 0.026 | < 0.001 (< 0.001 - > 999.999) | 0.989 |
Abbreviations: BI-RADS, breast imaging reporting and data system; IDC, invasive ductal carcinoma; MMG, mammographic; TN, triple negative; US, ultrasound; OR, odds ratio; HER2, human epidermal growth factor receptor 2; CI, confidence interval; IHC, immunohistochemical.