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. 2016 Oct;11(10):1617–1624. doi: 10.4103/1673-5374.193241

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Copyright: © Neural Regeneration Research

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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Activation of β₂AR restores dendritic branches and spine density in the hippocampus.

The mice were sacrificed, and Golgi staining was used to detect the dendrites and spines in the hippocampus. (A) Golgi-stained hippocampal pyramidal neurons; scale bars: 50 μm. (B) The number of dendritic branches was quantified from randomly selected neurons (Golgi staining). (C) Dendritic spines of different hippocampal pyramidal neurons; scale bars: 10 μm. (D) The number of dendritic spines was quantified from randomly selected dendritic segments of neurons (Golgi staining). Data are expressed as the mean ± SD (n = 3; one-way analysis of variance followed by least significant difference post hoc tests). **P < 0.01, vs. Con; #P < 0.05, vs. APP/PS1. Con: Control; β₂AR: β₂-adrenoceptor; APP/PS1: amyloid precursor protein/presenilin 1; Clen: clenbuterol.