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. 2016 Nov 1;143(21):3994–4002. doi: 10.1242/dev.137760

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© 2016. Published by The Company of Biologists Ltd

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Fig. 4. — Overexpression of Fgf10 in Chx10-Cre;Lhx2^lox/lox;pMes-Fgf10 animals rescued lens fiber development. Developmental time-course of immunohistochemical staining for Prox1 (green) and β-crystallin (red) in lenses at E11.5 (A-D), E12.5 (E-H), E13.5 (I-L), E15.5 (M-P), E18.5 (Q-T) and P0.5 (U-X) of Chx10-Cre;Lhx2^lox/+ (A,E,I,M,Q,U), Chx10-Cre;Lhx2^lox/+;pMes-Fgf10 (B,F,J,N,R,V), Chx10-Cre;Lhx2^lox/lox (C,G,K,O,S,W) and Chx10-Cre;Lhx2^lox/lox; pMes-Fgf10 (D,H,L,P,T,X) animals . Nuclei are counterstained with DAPI (blue). Scale bars: 100 µm.