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. 2016 Nov 1;143(21):3933–3943. doi: 10.1242/dev.139253

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© 2016. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 10. — Bone malformations upon Vegf overexpression. (A) Cryostat cross-sections of humeri from wild-type and Vegf-OE mice at E18.5 immunostained for blood vessels (red) show expansion of the vascular patterning domain in the mutant. (B) Cross-sectional views of three-dimensional reconstructions from micro-CT scans of humeri from E18.5 wild-type (left) and Vegf-OE (right) mice illustrate the abnormal arrangement of the primordial cortex in the mutant. (C) Cross-sections of E17.5 humeri immunostained for blood vessels (red) and COL1A1 (white) show discontinuous collagen type I distribution in the mutant. (D) Magnifications of the boxed areas demonstrate collagen I association with ECs in both wild type and mutant. Scale bars: 100 µm in A-C; 20 µm in D.