Fig. 4.

Analysis of iDamIDseq results on Rx2. (A) Samples showed high correlations between replicates and low correlations between Rx2 and GFP, based on the genome-wide read coverage. (B) The most overrepresented motif found de novo has a consensus sequence BYAATTA, very similar to the binding motif known for the mammalian Rax protein. (C) Abundance of the RAX motif in the identified sites, with respect to random sequence, correlates with the score of these regions. The Rx2-enriched sites identified by iDEAR show a higher enrichment than those represented by MACS2 and the Marshall and Brand pipeline.