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. 2016 Nov 1;9(11):1271–1281. doi: 10.1242/dmm.025288

Fig. 6.

Fig. 6.

In vivo expression of IRA in hepatocytes reverts compensatory beta cell hyperplasia. (A) Plasma insulin levels in 16-h-fasted 9-month-old mice. Data are means±s.e.m. for each experimental group (n=12). #P<0.01, ##P<0.005 iLIRKO versus iLIRKO IRA by unpaired Student's t-test. (B) Representative insulin staining of pancreatic sections from 9-month-old mice of the four groups studied. Image magnification: 10×. (C-E) Fractional beta cell area (C), Islet density (D) and Islet size distribution (E) of control, iLIRKO, iLIRKO IRA and iLIRKO IRB mice. Data are means±s.e.m. for each experimental group (n=5). *P<0.05, ***P<0.001 control versus iLIRKO; #P<0.05 iLIRKO versus iLIRKO IRA; $P<0.05, $$P<0.005, $$$P<0.001 iLIRKO versus iLIRKO IRB by unpaired Student's t-test.