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. 2016 Nov 1;9(11):1339–1348. doi: 10.1242/dmm.027227

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© 2016. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 3. — Increased number of Schwann cells in mct8^−/− larvae during development. (A) Lateral view of a motor neuron in 10-dpf live tg(mbp:EGFP)/tg(huc:GAL4 x uas:tagRFP) larvae shows Schwann cell (green) ensheathment of motor neuron axons (red). (B) Representative lateral-view images of Schwann cell ensheathment of motor neuron axons in the SC of 10-dpf mct8^+/+ and mct8^−/− larvae. (C) Number of Schwann cells that myelinate the axons of the motor neurons of 4 (mct8^+/+: n=9, mct8^−/−: n=9)- and 10 (mct8^+/+: n=26, mct8^−/−: n=22)-dpf larvae. (D) Number of Schwann cells that myelinate the axons of the motor neurons of untreated and T3-treated mct8^+/+ 10-dpf larvae (untreated: n=26, T3-treated: n=19). Values are represented as means±s.e.m. Statistical significance was determined by Student's t-test: two samples assuming unequal variance (*P<0.05, ***P<0.001). Scale bars: 10 µm.