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. 2016 Nov 15;12:1744806916679166. doi: 10.1177/1744806916679166

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© The Author(s) 2016

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — Intraperitoneal (i.p.) injection of minocycline attenuated single prolonged stress (SPS)-induced mechanical allodynia and anxiety-like behavior. (a) Pain sensitivity was determined by measuring paw withdrawal mechanical threshold (PWMT) on the day before SPS (baseline) and on days 1, 2, 3, 5, 7 after SPS. (b) The data of PWMT was also expressed as the hyperalgesic index. Anxiety-like behavior was tested in the EPM on day 7 after SPS. Percentage (%) of open-arm entries (c) and time spent in the open arms (d) as well as anxiety index (e) were calculated. Data were expressed as the mean ± standard deviation; n = 8 in each group. *P < 0.05, **P < 0.01, ***P < 0.001 compared with group control + vehicle i.p.; ^#P < 0.05, ^##P < 0.01, ^###P < 0.001 compared with group SPS + vehicle i.p.