Skip to main content
. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Pediatr Infect Dis J. 2016 Apr;35(4):414–421. doi: 10.1097/INF.0000000000001022

FIGURE 3.

FIGURE 3

Area under the concentration versus time curve for the unbound drug obtained at steady state (fAUCss,0–24) following for various daily doses of levofloxacin (5, 10, 15, and 20 mg/kg). The lower, middle, and upper solid lines represent the median fAUCss,0–24 reported for adults following 500 mg once daily dosing, 750 mg once daily, and 1,000 mg once daily, respectively. An estimate for the 1000 mg daily dose was obtained from Peloquin et al. (1), while the estimates for 500 mg and 750 mg daily doses were obtained from clinical review documents [3 and 18]. A fraction unbound of 0.75 was assumed to calculate unbound exposure.