TABLE 2.
Levofloxacin noncompartmental pharmacokinetic parameters in 50 study participants1, Federated States of Micronesia (FSM), and Republic of the Marshall Islands (RMI), 2009–2011.
| AGE (years) |
n | LAMBDA_Z (hours−1) |
V/F (liters/kg) |
CL/F (liters/hour/kg) |
Half-life (hours) |
CMAX (µg/ml) |
TMAX (hours) |
AUC0–6 (hours*µg/ml) |
|---|---|---|---|---|---|---|---|---|
| 0·5 – <2 | 3 | 0·39 (0·31) | 0·74 (0·46) | 0·26 (0·15) | 2·46 (1·38) | 13·54 (3·58) | 1 (0) | 52·47 (23·18) |
| 2 – <5 | 7 | 0·19 (0·05) | 1·24 (0·43) | 0·24 (0·11) | 3·83 (1·12) | 10·58 (3·62) | 1·14 (0·38) | 44·79 (15·20) |
| 5 – <10 | 18 | 0·18 (0·07) | 1·49 (0·73) | 0·23 (0·07) | 4·89 (3·08) | 6·77 (2·69) | 1·44 (0·51) | 28·18 (10·22) |
| 10 – <12 | 5 | 0·18 (0·05) | 1·36 (0·30) | 0·25 (0·12) | 4·03 (0·89) | 6·95 (1·97) | 1·2 (0·45) | 29·37 (9·25) |
| 12 – <17 | 17 | 0·14 (0·05) | 1·38 (0·44) | 0·18 (0·06) | 5·45 (1·69) | 7·41 (2·17) | 1·35 (0·49) | 32·17 (10·90) |
1
Parameter estimates are shown as mean (standard deviation). The upper bound for each age group is inclusive.