Fig. 10.

ADPKD upregulates signal transduction. NC-ADPKD and C-ADPKD cells have higher-than-normal expression of genes from all signal transduction gene sets. Expression levels in NC-ADPKD cells are intermediate between those of NK and C-ADPKD cells, exception that expression levels of Wnt and Notch signaling pathways are higher in NC-ADPKD cells. These pathways are normally active primarily during embryonic development. We present data as mean ± s.e.m., **P < 0.01, *P < 0.05 (black asterisk is in comparison to NK, gray asterisk is in comparison to NC-ADPKD). Signal Transduction Gene Sets: (1) G_PROT._COUPLED_RECEPTOR_PROTEIN_SIGNALING, (2) G_PROT._SIGNALING_COUPLED_TO_CYCLIC_NUCLEOTIDE_2ND_MESS, (3) G_PROT._SIGNALING_COUPLED_TO_CAMP_NUCLEOTIDE_2ND_MESS, (4) G_PROT._SIGNALING_ADENYLATE_CYCLASE_ACTIVATING, (5) CAMP_MEDIATED_SIGNALING, (6) CELL_CELL_SIGNALING, (7) SYNAPTIC_TRANSMISSION, (8) CYCLIC_NUCLEOTIDE_MEDIATED_SIGNALING, (9) KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION, (10) KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION, (11) KEGG_ERBB_SIGNALING_PATHWAY, (12) KEGG_WNT_SIGNALING_PATHWAY, (13) KEGG_NOTCH_SIGNALING_PATHWAY, (14) KEGG_CALCIUM_SIGNALING_PATHWAY, (15) KEGG_JAK_STAT_SIGNALING_PATHWAY, (16) KEGG_ABC_TRANSPORTERS