Fig. 6.

Relative transcriptogram for C-ADPKD/NC-ADPKD. The x-axis indicates the relative positon in the ordered list of 9684 genes. Upper panel The relative transcriptograms are presented as means ± s.e.m. with C-ADPKD (red line ± pink region) and NC-ADPKD (blue line ± cyan region) relative to NC-ADPKD. Center panel (shaded gray): P value from a two tailed Weyl’s t test for each point of the transcriptogram. Horizontal lines mark P = 0.05 and P = 0.01. We label the location in the ordered list of Pkd1 and Pkd2, the causative genes for ADPKD. Lower panel: Term enrichment for transcriptogram regions with gene expression significantly different from normal. A term enrichment value of 1 on the y-axis indicates that all genes in an interval of radius r = 30 participate in a given GO term or KEGG pathway. P values between C-ADPKD and NC-ADPKD cells are smaller than between either C-ADPKD or NC-ADPKD and NK cells (see Figs. 4 and 5) because C-ADPKD and NC-ADPKD cells were derived from the same individual, allowing us to discriminate additional differentially expressed regions