Table 2.
KEGG pathways and GO terms identified as differentially expressed by GSEA analysis
| Size | ES | NES | Normal P value | FDR | FWER P value | |
|---|---|---|---|---|---|---|
| NC-ADPKD/NK, upregulated in NK | ||||||
| KEGG_drug_metabolism_cytochrome_p450 | 42 | 0.8 | 2.17 | 0 | 0 | 0 |
| KEGG_metabolism_of xenobiotics_by_cytochrome p450 | 42 | 0.7 | 2.06 | 0 | 0 | 0.001 |
| KEGG_histidine_metabolism | 22 | 0.8 | 1.94 | 0 | 0.006 | 0.019 |
| KEGG_glutathione_metabolism | 38 | 0.7 | 1.86 | 0 | 0.013 | 0.049 |
| KEGG_fatty_acid_metabolism | 32 | 0.6 | 1.73 | 0.004 | 0.048 | 0.209 |
| C-ADPKD/NK, upregulated in C-ADPKD | ||||||
| KEGG_chemokine_signaling_pathway | 144 | −1 | −1.73 | 0 | 0.01 | 0.011 |
| KEGG_axon_guidance | 99 | −1 | −1.68 | 0 | 0.03 | 0.066 |
| KEGG_leukocyte_transendothelial_migration | 86 | −1 | −1.66 | 0.001 | 0.028 | 0.092 |
| GOBP_cell_cell_adhesion | 48 | 0.8 | 1.8 | 0 | 0.001 | 0.001 |
| NC-ADPKD/C-ADPKD, upregulated in C-ADPKD | ||||||
| KEGG_leukocyte_transendothelial_migration | 86 | −1 | −1.82 | 0 | 0 | 0 |
| KEGG_chemokine_signaling_pathway | 144 | −1 | −1.74 | 0 | 0.024 | 0.05 |
| KEGG_tight_junction | 101 | −1 | −1.73 | 0 | 0.02 | 0.063 |
| KEGG_axon_guidance | 99 | −1 | −1.73 | 0 | 0.016 | 0.066 |
| GOBP_cell_cell_adhesion | 48 | 0.8 | 1.8 | 0 | 0.007 | 0.008 |
Listing of KEGG pathways and GO terms with FDR < 5 %. GSEA expresses all differences as upregulation to minimize class bias due to the intrinsic asymmetry of the method