Fig. 6.

Mesenchymal lineage signature. a Venn Diagrams showing the cross-flow of differentially expressed genes from the three approaches presented that contrast MSCs to HSPCs. Colour code for tissue-MSCs: BM (red), PL (blue), AD (green). b Summary table of enrichment in biological terms (MG = Metagroup): Metagroup refers to a functional cluster that gathers functionally associated genes from the mesenchymal lineage signature. The same MG colour code is applied in the network. The value Silhouette width measures the closeness between biological terms within each metagroup. The higher the Silhouette width, the more closely related are the metagroup terms. P-values give the enrichment significance to each metagroup. c Functional network. Ball-nodes represent genes. Links represent functional association between genes based on shared biological annotations. Squared nodes represent the metagroups of genes sharing functional annotations. Conservation information per gene (based on exonic sequences) has been implemented under a yellow-blue scale, from less to highly conserved scores, respectively