Table 5.

Comparison of fibroblastic signatures previously published against our differentially expressed genes in equivalent contrasts

Reference	Organism	Cells types in contrast	DE features	Statistical significance threshold	Observations	Overlap of genes detected in FIB versus MSCs signatures of different tissue origen studied in this work
Wagner et al. 2005 [7]	Human	HS68-FIB against all tissue MSCs (BM-MSC-M1; BM-MSC-M2; AD-MSC-M1; CB-MSC-M3)	30 genes UP in FIB (based on 206 ESTs)	> 4-fold change	Human Transcriptome Microarray representing 51,144 different cDNA clones of the UniGene set RZPD3 (two colour arrays). M1, M2 & M3 refer to different culture conditions.	9 genes UP in FIB vs MSCs: APCDD1, CCRL1, KIT, MMP1, MMP3, MOXD1, PSG3, PSG9, TBX5,
Jääger et al. 2012 [41]	Human	AD-MSC vs FIB	119 genes UP in FIB	ANOVA (5% FDR)	Multiplex mRNA-sequencing	14 genes UP in FIB vs MSCs: ANPEP, CDC25B, CLDN11, CTSK, CXCL12, DNM1, IGFBP3, MMP3, PBX3, S100A4, SLIT2, STEAP1, TRAF3IP2, VIT
Wagner et al. 2005 [7]	Human	All tissue MSCs (BM-MSC-M1; BM-MSC-M2; AD-MSC-M1; Cord Blood MSC-M3) vs HS68-FIB	25 genes UP in MSCs (based on 47 ESTs)	> 2-fold change	Human Transcriptome Microarray representing 51,144 different cDNA clones of the UniGene set RZPD3 (two colour arrays). M1, M2 & M3 refer to different culture conditions.	4 genes DOWN in FIB vs MSCs: GPC4, HOXA5, PLOD2, TM4SF1
Jääger et al. 2012 [41]	Human	AD-MSC vs FIB	59 genes UP in AD-MSC	ANOVA (5% FDR)	Multiplex mRNA-sequencing	13 genes DOWN in FIB vs MSCs: BGN, CDH2, GGT5, ID3, COL4A1, COL5A1, COL11A1, KRT18, LOXL2, NDFIP2, TAGLN, TNS1, TPM1

Genes appearing in more than one published signature are highlighted in bold