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. 2016 Nov 21;13:81. doi: 10.1186/s12977-016-0312-7

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Domain swapping experiments to determine minimal region of JRFL, which confers CD4-bs-directed bNAb binding on JRCSF. a Schematic representation of domain swapped mutants. b–d FACS-based cell surface staining assay of JRFL, JRCSF and domain swapped mutants with the neutralizing Abs 2G12, VRC01, b12 and the non-neutralizing Ab F105 over a range of antibody concentrations