Fig 1. Naïve individuals are High- or Low- IFN-γ producers upon stimulation with Leishmania braziliensis promastigotes.

PBMCs were cultured with L. braziliensis for 72h (Lb) or left unstimulated (Unst). Supernatants were collected and IFN-γ levels were determined by ELISA. Data from one representative experiment are shown individually for High Producers (HP) (n = 4) and Low Producers (LP) (n = 5). Samples from three HP (orange) and three LP (blue) individuals, depicted as triangle, diamond and circle were used in subsequent experiments.