Table 1.
Overview of proposed host-symbiont interaction proteins
| Functional category | Protein family | Transcripts a) | Proteins b) |
|---|---|---|---|
| Pattern recognition proteins | |||
| peptidoglycan recognition proteins (PGRPs) | 6 (16) | 1 | |
| C-type lectins | 33 (119) | 5 | |
| R-type lectins | 6 (18) | 4 | |
| SUEL/rhamnose-binding lectins | 7 (22) | 1 | |
| galectins | 3 (3) | 1 | |
| fucolectin | 1 (23) | 0 | |
| fibrinogen-related proteins (FREPs) | 27 (161) | 1 | |
| toll-like/variable lymphocyte receptor-like (TLR/VLR) | 13 (52) | 1 | |
| scavenger receptor cysteine-rich (SRCR) domain proteins | 25 (164) | 1 | |
| beta-1,3-glucan binding protein | 1 (1) | 1 | |
| novel immunoglobulin I-set proteins | 16 (17) | 1 | |
| novel immunoglobulin V-set proteins | 9 (22) | 1 | |
| Antimicrobial proteins | |||
| lumbricin | 1 (1) | 1 | |
| invertebrate-type lysozyme | 1 (1) | 0 | |
| bactericidal permeability increasing protein BPI | 1 (3) | 1 | |
| insect defensin/reeler-like proteins | 4 (8) | 1 | |
| cysteine-rich secretory proteins (CRSPs) | 6 (28) | 2 | |
| membrane attack complex/perforin | 2 (23) | 0 | |
| Other immune effectors | |||
| ROS modulator 1 | 2 (3) | 1 | |
| alpha-2-macroglobulin | 10 (24) | 1 | |
| kazal-type serpin | 2 (8) | 0 | |
| kunitz-type serpin | 1 (2) | 0 | |
| leukocyte elastase inhibitors | 5 (25) | 1 | |
| phosphatidylethanolamine-binding protein PEBP | 3 (5) | 1 | |
| Immune response regulators | |||
| Toll/interleukin-1 receptor (TIR) domain proteins | 5 (9) | 0 | |
| NF-kappa-B inhibitor Cactus | 2 (6) | 0 | |
| dorsal protein | 2 (3) | 1 | |
| evolutionarily conserved signaling intermediate in Toll (ECSIT) | 1 (1) | 0 | |
| Pelle protein | 1 (1) | 0 | |
| Relish protein | 1 (6) | 0 | |
| mitogen-activated protein kinase kinase kinase 7 (TAK1) | 1 (1) | 0 | |
| I-kappa-B-kinase alpha (IKK α) | 1 (1) | 0 | |
| I-kappa-B-kinase beta (IKK β) | 1 (5) | 0 | |
| interleukin-1 receptor-associated kinase 1 (IRAK1) | 1 (2) | 0 | |
| mitogen-activated protein kinase kinase kinase 4 (MEKK4) | 1 (1) | 0 | |
| sterile alpha and TIR motif-containing protein (SARM) | 1 (3) | 0 | |
| Toll-interacting protein Tollip | 1 (2) | 1 | |
| (LPS-induced) tumor necrosis factor (TNF) | 3 (7) | 0 | |
| Tumor necrosis factor (TNF) | 4 (6) | 0 | |
| tumor necrosis factor alpha-induced protein 3 (TNFAIP3) | 1 (3) | 0 | |
| tumor necrosis factor receptor associated proteins (TRAF) | 9 (16) | 0 | |
| IFN regulatory factor | 8 (10) | 0 | |
| IFN regulatory factor-binding protein | 1 (1) | 0 | |
| IFN-induced GTPase | 7 (23) | 1 | |
| macrophage migration inhibitory factor (MIF) | 3 (24) | 1 | |
| ILN enhancer binding factor 2 | 2 (4) | 1 | |
| ILN-16 | 1 (1) | 0 | |
| Digestive enzymes | |||
| carboxypeptidases | 11 (22) | 0 | |
| cathepsins total | 15 (28) | 4 | |
| cathepsin B | 3 (12) | 1 | |
| cathepsin C | 2 (4) | 0 | |
| cathepsin F | 3 (3) | 1 | |
| cathepsin L | 5 (6) | 2 | |
| cathepsin O | 1 (2) | 0 | |
| cathepsin Z | 1 (1) | 0 | |
| chymotrypsins | 3 (17) | 1 | |
| pancreatic elastase | 1 (1) | 1 | |
| alpha amylase | 2 (3) | 1 | |
| lysosomal alpha glucosidase | 1 (3) | 1 | |
| acid trehalase | 2 (4) | 1 | |
| sucrase-isomaltase | 1 (1) | 0 | |
| lysosomal acid lipase | 1 (1) | 0 | |
| Respiration | |||
| hemerythrin | 2 (2) | 2 | |
| giant extracellular hemoglobin, globin chains | 12 (16) | 8 | |
| giant extracellular hemoglobin, linker chains | 6 (18) | 5 | |
| sum | 316 (1032) | 60 | |