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. 2016 Nov 21;9:252. doi: 10.1186/s13068-016-0665-0

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — CoReCo metabolic model reconstruction pipeline. The algorithm has three main inputs: (1) genomes of the organisms (set of proteins), (2) phylogeny of the organisms, and (3) reaction database containing lists of metabolic reactions, reaction directionalities, and sequences of the enzymes catalyzing the reactions