Table 4. Comparison of the pre- and 24-week post-therapy variables in CHC patients stratified by the therapeutic response.
| SVR (+) (n = 395) | Paired t-test p-values | SVR (-) (n = 79) | Paired t-test p-values | |||
|---|---|---|---|---|---|---|
| Pre-therapy value | Post-therapy value | Pre-therapy value | Post-therapy value | |||
| BMI | 24.77+/-3.65 | 24.36+/-3.53 | <0.001* | 25.84+/-4.10 | 24.86+/-3.60 | <0.001* |
| AST (U/L) | 73.08+/-62.01 | 26.21+/-11.15 | <0.001* | 74.93+/-64.40 | 73.37+/-66.06 | 0.841 |
| ALT (U/L) | 97.40+/-88.67 | 21.64+/-14.70 | <0.001* | 81.60+/-64.52 | 71.20+/-67.80 | 0.799 |
| TC (mg/dL) | 171.68+/-32.67 | 186.97+/-36.09 | <0.001* | 173.54+/-29.79 | 171.85+/-32.81 | 0.615 |
| HDL (mg/dL) | 48.15+/-13.80 | 49.85+/-13.35 | <0.001* | 48.83+/-14.82 | 49.91+/-14.77 | 0.314 |
| TG (mg/dL) | 101.35+/-46.74 | 120.73+/-75.58 | <0.001* | 115.97+/-66.98 | 104.79+/-47.70 | 0.069 |
| HOMA-IR | 2.88+/-4.75 | 2.74+/-2.98 | 0.374 | 4.50+/-5.94 | 4.69+/-7.81 | 0.703 |
| Uric acid (mg/dL) | 5.89+/-1.52 | 6.13+/-1.54 | <0.001* | 5.88+/-1.48 | 5.89+/-1.46 | 0.9 |
| WBC count (103/μL) | 5.85+/-1.94 | 5.83+/-1.81 | 0.801 | 5.56+/-1.69 | 5.13+/-1.26 | 0.032* |
| Platelets (103/μL) | 182.3+/-58.78 | 184.53+/-56.51 | 0.239 | 154.9+/-58.73 | 148.9+/-54.2 | 0.203 |
| hsCRP (mg/dL) | 1.59+/-2.73 | 1.78+/-4.46 | 0.494 | 1.58+/-1.99 | 1.90+/-3.64 | 0.436 |
| C3 (mg/dL) | 107.2+/-19.74 | 108.6+/-17.39 | 0.169 | 101.9+/-16.66 | 102.6+/-17.58 | 0.677 |
| C4 (mg/dL) | 20.32+/-7.30 | 21.55+/-7.07 | <0.001* | 19.08+/-7.77 | 19.47+/-8.33 | 0.536 |
| APRI | 1.47+/-1.65 | 0.50+/-0.39 | <0.001* | 1.76+/-1.84 | 1.71+/-1.75 | 0.845 |
| Hepatic steatosis (yes) | (51) | (52) | 0.630 | (43) | (49) | 0.288 |
| Leptin (pg/mL) | 9441.4+/-8992.8 | 9809.4+/-9448.8 | 0.543 | 10229.7+/-10528.5 | 10821.7+/-12650.4 | 0.763 |
| Log leptin (Log10pg/mL) | 3.74+/-0.55 | 3.77+/-0.54 | 0.392 | 3.83+/-0.38 | 3.85+/-0.40 | 0.835 |
SVR: sustained virological response; Log: log transformation; BMI: body mass index; AST: aspartate aminotransferase; ALT: alanine aminotransferase; TC: total cholesterol; HDL: high-density lipoprotein cholesterol; TGs: triglycerides; HOMA-IR: homeostasis model assessment-estimated insulin resistance; WBC: white blood cell; hsCRP: high-sensitivity C-reactive protein; C3: complement component 3; C4: complement component 4; APRI: AST to platelet ratio index; SNP: single nucleotide polymorphism
*: p<0.05.