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Summary of RAD51 surrogate systems. The “jigsaw puzzle pieces” with green (RAD51) and orange (RadA) colouring illustrate the progress of humanisation and ChimRAD51 development. Different mutants have served different purposes in our drug discovery programme, as labelled in the diagram. This summary illustrates our experience that more than one protein or protein form is needed to enable all the diverse analyses required for modern structure-guided drug discovery.
