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. 2016 Oct 14;38(6):1683–1692. doi: 10.3892/ijmm.2016.2771

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Copyright: © Ahmad et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Downregulation of cystathionine-β-synthase (CBS) attenuates the lipopolysaccharide (LPS)-induced increases in blood urea nitrogen (BUN) plasma levels in mice. BUN levels in wild-type (WT), CBS heterozygous (CBS^+/−), cystathionine-γ-lyase (CSE) knockout (CSE^−/−) and 3-mercaptopyruvate sulfurtransferase (3MST) mutant (Δ3MST) mice treated with vehicle or LPS (10 mg/kg, 6 h). LPS significantly impaired glomerular function, as evidenced by markedly increased BUN concentration; this increase was reduced in CBS^+/− mice. Data are shown as mean ± standard error of the mean (SEM) of 10 animals; ^*p<0.05 shows significant increases in response to LPS, compared to the vehicle control; ^#p<0.05 shows a significant protective effect of the CBS^+/− phenotype compared to WT.