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. 2016 Oct 14;38(6):1683–1692. doi: 10.3892/ijmm.2016.2771

Figure 7.

Figure 7

Downregulation of 3-mercaptopyruvate sulfurtransferase (3MST) increases the lipopolysaccharide (LPS)-induced increases in plasma interleukin (IL)-5 and granulocyte-macrophage colony-stimulating factor (GM-CSF) levels in mice. Plasma (A) IL-5 and (B) GM-CSF levels in wild-type (WT), cystathionine-β-synthase (CBS) heterozygous (CBS+/−), cystathionine-γ-lyase (CSE) knockout (CSE−/−) and 3MST mutant (Δ3MST) mice treated with the vehicle or LPS (10 mg/kg, 6 h). LPS significantly increased IL-5 and GM-CSF levels; the effect was more pronounced in the Δ3MST mice than in the WT controls. Data are shown as the means ± standard error of the mean (SEM) of 10 animals; *p<0.05 shows significant increases in response to LPS, compared to the vehicle control; #p<0.05 shows significantly higher cytokine responses in the Δ3MST mice compared to the WT controls.