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. 2016 Oct 14;38(6):1683–1692. doi: 10.3892/ijmm.2016.2771

Figure 8.

Figure 8

Downregulation of cystathionine-β-synthase (CBS), cystathionine-γ-lyase (CSE) or 3-mercaptopyruvate sulfurtransferase (3MST) attenuates the lipopolysaccharide (LPS)-induced increases in plasma interleukin (IL)-10, but not IL-6 levels in mice. Plasma (A) IL-6 and (B) IL-10 levels in wild-type (WT), CBS heterozygous (CBS+/−), CSE knockout (CSE−/−) and 3MST mutant (Δ3MST) mice treated with the vehicle or LPS (10 mg/kg, 6 h). LPS significantly increased IL-6 and IL-10 levels; the increase in IL-10 was reduced in CBS+/−, CSE−/− and Δ3MST mice. Data are shown as the means ± standard error of the mean (SEM) of 10 animals; *p<0.05 and **p<0.01 show significant increases in response to LPS, compared to the vehicle control; #p<0.05 shows a significant protective effect of the CSE−/−, CBS+/− and Δ3MST phenotype compared to WT.