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. 2016 Nov 2;38(6):1661–1672. doi: 10.3892/ijmm.2016.2794

Figure 1.

Figure 1

Bergapten suppresses diabetes mellitus-induced systemic inflammtion and metabolic disorders in mice with diabetes-related osteoporosis (DO) and mice with DO and osteoprotegerin (OPG)-KO. (A) Chemical structure of bergapten. (B) Insulin tolerance test (ITT) for serum glucose levels. (C) Oral glucose tolerance test (OGTT) for serum glucose levels. (D) Biochemical analysis of lipid metabolic indicators. (E) ELISA for interleukin (IL)-2, IL-4, IL-6, IL-1 and IL-1β protein expression. (F) ELISA for tumor necrosis factor-α (TNF-α), interferon (IFN)-γ, IL-17 and IL-10 protein expression. (G) Oil Red O staining for analysis of liver tissue of mice fed a high-fat diet. #p<0.05, ##p<0.01, ###p<0.001 vs. normal group; *p<0.05, vs. DO and DO + OPG(−/−) group.