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Osteoprotegerin (OPG) knockout promotes the activatio of the JNK/MAPK signaling pathway in mice with high-fat diet-induced diabetes-related osteoporosis (DO) and with DO and OPG-KO. (A and B) qPCR of the mRNA expression levels of TRAF6 and JNK1. (C) Western blot analysis of the protein expression of JNK1/2. #p<0.05 and ##p<0.01 vs. normal group.
