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. 2016 Nov 21;11(11):e0167098. doi: 10.1371/journal.pone.0167098

Fig 1. Effects of YPL-001(YPL) and picroside II (PIC II) on House dust mite (HDM)-induced BALF composition.

Fig 1

(A) A timeline of allergen sensitization, exposure, and drug treatment in this study (DEX; dexamethasone, i.n; intranasal). The total cells (B) and differential cells (C) in BALF of mice were collected at 48h after the last HDM challenge, and quantified in DiffQuick-stained reagent. NC; normal control mice treated with saline only, model; HDM-sensitized/challenged mice, YPL 15 and 30; YPL-001 (15 and 30 ㎎/㎏) + HDM-sensitized/challenged mice, PIC 15 and 30; picroside II (15 and 30 ㎎/㎏)+HDM-sensitized/challenged mice, DEX; dexamethasone + HDM-sensitized/challenged mice. All data are representative of three independent experiments and represented as the mean ± SEM (n = 6 mice/group). #p<0.05, ##p<0.01, and ###p<0.001, compared with normal control (NC); *p<0.05, **p<0.01, and ***p<0.001, compared with model group.

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