Table 4. Seropositivity of polyomaviruses and association with lung cancer stratified by interval between sample collection and cancer diagnosis.
| Cases n (%) | Controls n (%) | Odds ratio (95% CI) | P-value | |
|---|---|---|---|---|
| ⩽5 years | ||||
| JCV (VP1) | 101 (74.8) | 98 (73.1) | 1.09 (0.63–1.88) | 0.75 |
| BKV (VP1) | 125 (92.6) | 119 (88.8) | 1.58 (0.68–3.64) | 0.29 |
| KI (VP1) | 109 (80.7) | 109 (81.3) | 0.96 (0.52–1.77) | 0.9 |
| WU (VP1) | 131 (97.0) | 128 (95.5) | 1.54 (0.42–5.57) | 0.51 |
| TSV (VP1) | 100 (74.1) | 101 (75.4) | 0.93 (0.54–1.62) | 0.81 |
| MCV (VP1) | 75 (55.6) | 74 (55.2) | 1.01 (0.63–1.64) | 0.96 |
| HPyV6 (VP1) | 105 (77.8) | 102 (76.1) | 1.10 (0.62–1.94) | 0.75 |
| HPyV7 (VP1) | 92 (68.2) | 83 (61.9) | 1.31 (0.80–2.17) | 0.29 |
| HPyV10 (VP1) | 129 (95.6) | 126 (94.0) | 1.37 (0.46–4.05) | 0.58 |
|
5–10 years | ||||
| JCV (VP1) | 131 (76.2) | 125 (72.7) | 1.20 (0.74–1.95) | 0.46 |
| BKV (VP1) | 155 (90.1) | 159 (92.4) | 0.75 (0.35–1.58) | 0.45 |
| KI (VP1) | 142 (82.6) | 155 (90.1) | 0.52 (0.27–0.98) | 0.04 |
| WU (VP1) | 169 (98.3) | 167 (97.1) | 1.69 (0.40–7.17) | 0.48 |
| TSV (VP1) | 138 (80.2) | 127 (73.8) | 1.44 (0.87–2.39) | 0.16 |
| MCV (VP1) | 89 (51.7) | 102 (59.3) | 0.74 (0.48–1.13) | 0.16 |
| HPyV6 (VP1) | 133 (77.3) | 145 (84.3) | 0.64 (0.37–1.09) | 0.1 |
| HPyV7 (VP1) | 115 (66.9) | 119 (69.2) | 0.90 (0.57–1.41) | 0.64 |
| HPyV10 (VP1) | 162 (94.2) | 169 (98.3) | 0.29 (0.08–1.06) | 0.06 |
|
>10 years | ||||
| JCV (VP1) | 121 (59.3) | 126 (62.4) | 0.88 (0.59–1.31) | 0.53 |
| BKV (VP1) | 175 (85.8) | 178 (88.1) | 0.81 (0.46–1.45) | 0.49 |
| KI (VP1) | 183 (89.7) | 181 (89.6) | 1.01 (0.53–1.92) | 0.97 |
| WU (VP1) | 190 (93.1) | 197 (97.5) | 0.34 (0.12–0.97) | 0.05 |
| TSV (VP1) | 153 (75.0) | 159 (78.7) | 0.81 (0.51–1.29) | 0.38 |
| MCV (VP1) | 139 (68.1) | 137 (67.8) | 1.01 (0.67–1.54) | 0.95 |
| HPyV6 (VP1) | 155 (76.0) | 152 (75.3) | 1.04 (0.66–1.64) | 0.86 |
| HPyV7 (VP1) | 123 (60.3) | 130 (64.4 | 0.84 (0.56–1.26) | 0.4 |
| HPyV10 (VP1) | 201 (98.5 | 201 (99.5 | 0.33 (0.03–3.23) | 0.34 |
Abbreviations: BKV=BK virus; CI=confidence interval; HPyV6=human polyoma virus 6; HPyV7=human polyoma virus 7; HPyV10=human polyoma virus 10; JCV=JC virus; MCV=Merkel cell polyoma virus; n=number; TSV=trichodysplasia spinulosa-associated polyoma virus.
Seropositivity for each polyomavirus VP1 defined as MFI⩾250 and MFI⩾400 for each TAg (except for MCV small TAg where seropositive if MFI⩾200).