Table 3. ERR estimates for breast cancer incidence and mortality by birth cohort, US Radiologic Technologists study, 1983–2008.
| Year of birth | ERR at 100 mGya | 95% CI | P-value | Fitted excess cases | Observed cases | Mean dose (mGy) |
|---|---|---|---|---|---|---|
|
Incidence | ||||||
| Before 1930 | 0.16 | 0.03, 0.39 | 0.01 | 44.2 | 216 | 167 |
| 1930–1939 | −0.1 | <−0.3, 0.11 | 0.41 | −21 | 406 | 49 |
| 1940–1949 | −0.14 | <−0.5, 0.22 | 0.4 | −25.8 | 745 | 25 |
| 1950+ | −0.25 | <−0.5, 0.31 | 0.27 | −27.9 | 555 | 14 |
|
Phet=0.08 |
||||||
| Common ERR | 0.07 | −0.005, 0.19 | 0.09 | 54.3 | 1922 | 30 |
|
Mortality | ||||||
| Before 1930 | 0.26 | 0.08, 0.63 | <0.001 | 43.7 | 128 | 217 |
| 1930–1939 | 0.28 | −0.08, 0.89 | 0.26 | 19.5 | 159 | 51 |
| 1940–1949 | 1.61 | 0.20, 4.50 | 0.01 | 52.6 | 190 | 25 |
| 1950+ | 0.61 | <−0.5, 4.70 | >0.5 | 8.6 | 109 | 14 |
|
Phet=0.35 |
|
|
|
|||
| Common ERR | 0.31 | 0.11, 0.67 | <0.001 | 88.5 | 586 | 37 |
Abbreviations: BMI=body mass index; CI=confidence interval; ERR=excess relative risk; Phet=P-value of test for hetergeneity over birth cohorts.
Adjusted for attained age, birth cohort category, menopause status, family history of breast cancer, baseline BMI and use of hormone replacement therapy.