Table 5. GSA for sub-pathway of serum metabolites and prostate cancer (P<0.05).
| Sub-pathway | No. of contributing metabolites | P-value from GSA |
|---|---|---|
|
Overall prostate cancer | ||
| Fatty acid, branched | 2 | 0.016 |
| Tocopherol metabolism | 6 | 0.017 |
| Medium-chain fatty acid | 7 | 0.032 |
|
Aggressive prostate cancer | ||
| Fatty acid, branched | 2 | 0.015 |
| Tryptophan metabolism | 20 | 0.037 |
| Urea cycle; arginine and proline metabolism | 17 | 0.046 |
|
Non-aggressive prostate cancer | ||
| Tocopherol metabolism | 6 | 0.014 |
| Primary bile acid metabolism | 10 | 0.021 |
|
Overall prostate cancer in Caucasians | ||
| Tocopherol metabolism | 6 | 0.007 |
| Fatty acid, branched | 2 | 0.009 |
| Medium-chain fatty acid | 7 | 0.019 |
Abbreviation: GSA=gene-set analysis.