Table 2. Coefficients of the main dose effect on DTI changes from the multivariate linear fixed-effect model.
| WM Tracts | 95%ile (mean) dose vs. ΔAD% | 95%ile (mean) dose vs. ΔRD% | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
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| 3wkRT | 6wkRT | 1mPost | 6mPost | 18mPost | 3wkRT | 6wkRT | 1mPost | 6mPost | 18mPost | |
| ATR_L | -0.16 (-0.12) | 0.068 (0.081) | -0.24* (-0.11) | -0.028 (-0.065) | -0.11 (-0.17) | -0.0041 (0.022) | 0.15 (0.094) | -0.058 (-0.046) | 0.077 (0.049) | 0.13 (-0.027) |
| ATR_R | -0.15* (-0.092) | -0.050 (-0.026) | -0.056 (-0.083) | -0.15 (-0.012) | -0.17 (-0.14) | -0.092 (-0.070) | -0.025 (-0.024) | -0.046 (-0.038) | -0.15 (-0.032) | -0.11 (-0.11) |
| CCH_L | -0.062 (-0.11) | -0.19 (0.029) | -0.30* (-0.19) | -0.26* (-0.23) | -0.31* (-0.17) | 0.0082 (-0.070) | 0.0033 (0.074) | -0.28 (-0.18) | -0.17 (-0.12) | -0.21 (-0.060) |
| CCH_R | -0.20 (-0.020) | -0.11 (-0.010) | -0.16 (-0.23) | -0.33** (-0.088) | -0.40* (-0.36) | 0.074 (0.16) | -0.054 (0.062) | 0.042 (-0.10) | -0.21 (-0.14) | -0.36 (-0.069) |
| IFOF_A_L | -0.15* (-0.055) | -0.22** (-0.045) | 0.0088 (0.062) | -0.28* (-0.089) | -0.25 (-017) | -0.15 (-0.014) | -0.17 (-0.040) | -0.22 (-0.21) | -0.37* (-0.099) | -0.30 (-0.055) |
| IFOF_A_R | -0.24** (-0.11) | -0.17* (-0.014) | -0.18 (-0.017) | -0.16 (-0.023) | -0.16 (-0.042) | -0.10 (-0.017) | -0.19* (-0.019) | -0.21 (-0.11) | -0.21 (-0.012) | -0.18 (-0.12) |
| IFOF_P_R | -0.031 (0.023) | -0.011 (0.011) | -0.085 (0.011) | -0.060 (-0.0036) | -0.32* (-0.087) | -0.088 (0.025) | 0.077 (0.13) | 0.014 (-0.033) | 0.051 (0.17) | -0.12 (0.18) |
| ILF_L | -0.044 (-0.080) | 0.011 (-0.023) | -0.039 (-0.076) | -0.23* (-0.21*) | -0.10 (-0.16) | 0.11 (0.054) | 0.034 (0.063) | 0.030 (0.022) | -0.12 (-0.12) | -0.036 (-0.073) |
| ILF_R | -0.035 (0.014) | -0.044 (-0.0094) | -0.092 (-0.014) | -0.033 (0.031) | 0.0036 (-0.15) | -0.091 (0.030) | -0.11 (0.0027) | -0.22** (-0.11) | 0.012 (0.20) | -0.24 (-0.26) |
| AF_R | 0.028 (0.15) | 0.056 (0.13) | 0.17 (0.095) | 0.078 (-0.24*) | -0.23 (-0.19) | -0.13 (-0.15) | 0.049 (0.081) | -0.086 (0.036) | 0.18 (0.21) | -0.37** (-0.53**) |
| UNC_L | -0.12* (-0.052) | -0.073 (-0.067) | -0.11 (-0.15**) | -0.18* (-0.16*) | -0.30* (-0.22) | -0.059 (0.0054) | -0.064 (-0.087) | -0.10 (-0.26**) | -0.094 (-0.16*) | -0.18 (-0.18) |
| UNC_R | -0.058 (-0.034) | 0.040 (-0.065) | -0.078 (-0.054) | 0.0031 (-0.034) | -0.0042 (-0.10) | -0.019 (-0.052) | -0.060 (-0.080) | -0.14* (-0.16**) | 0.074 (-0.075) | 0.047 (-0.16) |
(1). Abbreviation for fibers (same abbreviations used from all tables and figures): A – Anterior, P – Posterior, L – Left, R – Right. AF -Arcuate Fasciculus, ATR – Anterior Thalamic Radiata, CCH - Cingulum Cingulate at Hippocampus, IFOF – Inferior Fronto-Occipital Fasciculus, ILF – Inferior Longitudinal Fasciculus, UNC – Uncinate Fasciculus.
(2). Bold fonts indicate significant correlations:
*
p<0.05,
**
p<0.01