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. Author manuscript; available in PMC: 2017 Mar 26.
Published in final edited form as: Nat Chem Biol. 2016 Sep 26;12(11):973–979. doi: 10.1038/nchembio.2200

Figure 4. MdnC uses ATP to catalyze the macrocyclization of the precursor peptide MdnA.

Figure 4

(a) Modelled ADP interacts with the C-domain and central domain of MdnC. The positions of Mg2+ and ADP are adapted from the aligned LysX structure (PDB entry 3VPD, 20% sequence identity). (b) Interactions of MdnC with the precursor peptide MdnA. The strictly conserved region of MdnA (PFFARFL) is well-resolved in the electron density map. Helix α7 and β9β10 hairpin of MdnC sandwich the helical region of the resolved MdnA leader peptide. Calculated mFo-DFc map is displayed at a 1.5σ contour level.