. Author manuscript; available in PMC: 2017 Nov 1.

Published in final edited form as: Obesity (Silver Spring). 2016 Nov;24(11):2399–2406. doi: 10.1002/oby.21651

Table 3. Summary measures of insulin sensitivity.

Summary measures of insulin sensitivity per tissue type are shown, with several different methods of calculation shown, including the percent suppression from the basal concentration, and the insulin concentration required to suppress 50% of the basal rate (IC 50).

	OB	PCOS
Peripheral insulin sensitivity
Glucose infusion rate (mg/kg/min)	7.9 (7.4,10.7)	5.1 (4.2, 6.8)^**
Glucose infusion rate (mg/lean kg/min)	14.5 (13.1,18.1)	9.4 (7.2,12.3)^**
Hepatic insulin sensitivity
Glucose IC 50 (IU/ml)	61±6	86±6⁺
% Suppression glucose (basal to 16mU/m²/min phase)	67 (57,82)	57 (54,71)
Adipose insulin sensitivity
Glycerol IC 50 (IU/ml)	76 (51, 94)	75 (49,147)
% Suppression glycerol (basal to 10mU/m²/min phase)	100 (92, 109)	93 (83, 112)
FFA IC 50 (IU/ml)	40 (36,45)	62 (50,82)⁺
% Suppression FFA (basal to 10mU/m²/min phase)	57±18	73±12⁺

Data is shown as mean ± standard error of the mean or median (25,75).

Significance is noted as

⁺

= <0.01–0.001,

^**

= <0.001