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. 2016 Nov 15;10:3755–3761. doi: 10.2147/DDDT.S115121

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© 2016 Yang et al. This work is published and licensed by Dove Medical Press Limited

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ZD55-IL-18 and DTIC demonstrated synergistic antitumor effects in melanoma A375 mouse xenografts.

Notes: (A) Tumor growth curve of melanoma A375 xenografts in nude mice in different treatment groups. (B) Final tumor weight of melanoma A375 xenografts in nude mice in different treatment groups. *P<0.05 compared to other groups. (C) Immunohistochemical staining of IL-18 and E1A in A375 xenografts in nude mice in different treatment groups. Scale bar 5 µm.

Abbreviations: DTIC, dacarbazine; IL-18, interleukin 18; PBS, phosphate-buffered saline; w, weeks.