Table 1.

Relationship between the clinical–pathological features and the skull base bone destruction in 449 cases with NPC

Clinical features	Skull base bone destruction		P-value
	Without	With
Age, years			0.843
<46	142	77
≥46	152	78
Sex			0.239
Male	208	101
Female	86	54
Pathology			0.725
Undifferentiated NKC	267	143
Differentiated NKC	27	12
Clinical stages			<0.001
I	23	0
II	113	0
III	118	54
IV	40	101
T-staging			<0.001
T1	57	0
T2	149	0
T3	74	58
T4	14	97
N-staging			0.340
N0	91	51
N1	105	53
N2	72	44
N3	26	7
Chemotherapy			<0.001
No	197	55
Yes	97	100
Distant bone metastases			0.036
No	280	143
Yes	14	12

Abbreviations: NKC, nonkeratinizing carcinoma; NPC, nasopharyngeal carcinoma.