Table 2. IC50 Values (μM) for All Compounds Derived from Concentration Response Curves of the Fraction of Growth Compared to Untreated Control after 9 h of Growth of the Indicated Strain and Conditiona.
| Cmpd | Newman aerobic | Newman anaerobic | ΔmenB |
|---|---|---|---|
| 1 | >60 | 13.5 (8.42–21.7) | 1.66 (0.491–5.63) |
| 1a | >60 | >60 | 35.6 (31.0–41.5) |
| 1b | >60 | >60 | >60 |
| 1c | >60 | >60 | >60 |
| 1d | >60 | >60 | >60 |
| 4a | >60 | 26.5 (21.9–32.1) | 15.7 (11.5–21.5) |
| 4b | >60 | 4.27 (3.39–4.65) | 3.3 (1.28–8.55) |
| 1e | >60 | >60 | >60 |
| 1f | >60 | >60 | >60 |
| 1g | >60 | >60 | >60 |
| 1h | >60 | >60 | >60 |
| 1i | >60 | 19.6 (16.9–22.8) | 8.69 (7.65–9.88) |
| 1j | >60 | 11.6 (10.2–13.0) | 6.63 (5.02–8.76) |
| 1k | >60 | 13.4 (12.3–14.7) | 5.89 |
| 1l | >60* | 28.8 (22.0–37.7) | 21.4 (13.9–32.8) |
| 2a | >60 | >60 | >60 |
| 2b | >60 | >60 | >60 |
| 2c | >60 | 24.0 (20.0–28.7) | 25.2 (7.84–81.2) |
| 2d | 42.5 (40.2–44.9) | 15.8 (15.3–16.4) | 9.33 (4.89–20.1) |
| 2e | >60 | >60 | >60 |
| 2f | >60 | >60 | >60 |
| 2g | >60 | >60 | >60 |
| 2h | >60 | >60 | >60 |
| 2i | >60 | >60 | >60 |
| 2j | >60 | >60 | >60 |
| 2k | >60 | >60 | >60 |
| 2l | >60 | >60 | >60 |
| 2m | >60 | >60 | >60 |
| 2n | >60 | 25.3 (23.4–27.2) | 29.7 (24.6–35.9) |
| 2o | 48.6 (37.9–62.3) | 11.6 (10.3–13.1) | 13.2 (10.4–16.6) |
| 3a | >60 | 20.8 (17.9–24.2) | 24.9 (10.2–60.4) |
| 3b | >60 | >60 | >60 |
a
Data were collected in triplicate.
Error values are represented as the 95% confidence interval. IC50 values greater than 60 μM could not be reliably determined because of solubility problems at high concentrations, and compounds with an IC50 > 60 μM are considered nontoxic.
*
IC50 close to 60 μM, but solubility issues prevented accurate determination.