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. 2016 Aug 17;24(12):1817–1825. doi: 10.1038/ejhg.2016.105

Figure 2.

Figure 2

BP and HR of EFNB2 KO mice. The BP and HR were measured every 2 min by telemetry for 24 h. The mean±SEM of daily BP and HR are shown. Parameters of all the time points in the 24-h period were evaluated by a mixed-effects linear model, with genotype, individual mouse, sex and time used as qualitative factors. P-values are indicated: *P<0.05; **P<0.01. The average age of mice of each group at the time of telemetry measurement and the number of each group (n) are indicated. (a) BP of male KO and WT mice. (b) BP and of female KO and WT mice. (c) BP differences between KO and WT mice and between males and females. The differences of SP, DP, and MAP of KO vs WT mice (difference=WT value−KO value) are shown. Negative values mean that the KO values are larger than those of WT. The differences between sexes (according to a mixed-effects linear model), if statistically significant, are indicated. (d) HR differences between KO and WT mice (left panel) and between males and females (right panel).