Table 1. Biometric characteristics and dose of study medication.

	Body	Cranial		Dose based on
Age	weighta	volumeb	Dose	Weight	Volume	Administration
(years)	(kg)	litres (l)	IU/day	IU/kg/day	IU/l/day	no of spraysc
1–3	10–15	1.0–1.1	20	1.3–2.0	18.2–20.0	2 dd 1
3–9	15–30	1.1–1.25	30	1.0–2.0	24.0–27.3	1 dd 2 + 1 dd 1
9–18	30–65	1.25–1.5	40	0.6–1.3	26.7–32.0	2 dd 2

^aEstimated body weight (based on ref. 18).

^bEstimated cranial volume (ref. 19).

^cOne nasal spray is 0.1 ml and contains 10 IU.