Table 2. Gene-based analysis of non-synonymous and damaging SORL1 variants in each of the demographic groups studied.

Test	Non-synonymous				PoD/PrD
	n	cMAF-A	cMAF-U	P-value	n	cMAF-A	cMAF-U	P-value
sEOAD
SKAT	4	0.041	0.016	0.055	4	0.041	0.016	0.055
sLOAD
SKAT	17	0.104	0.111	0.795	6	0.052	0.060	0.945
fLOAD
G-SKAT	45			0.097	17			0.362
SKATa	45			0.341	17			0.569

Abbreviations: cMAF-A, cumulative minor allele frequency in affected indivdiuals; cMAF-U, cumulative minor allele frequency in unaffected individuals; fLOAD, familiar late-onset Alzheimer's disease; n, number of SNPs included in kernel association test; PoD/PrD, possibly damaging/probably damaging according to Polyphen2; sEOAD, sporadic early-onset Alzheimer's disease; sLOAD, sporadic late-onset Alzheimer's disease.

^aFour principal components and kinship matrix were included as covariates to account for related individuals.