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. 2016 Jul 20;24(12):1810–1816. doi: 10.1038/ejhg.2016.89

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The simulation results for case-control data with varying prevalence (K) and number of QTLs. The x axis quantifies the genetic architecture for the base population, in which the cases and the controls are sampled. The y axis represents the heritability on the liability scale. The x axis reflects the genetic architecture: negative/positive LD indicates the repulsion/coupling genetic architecture; LD=0 indicates the neutral genetic architecture. Of note, when , it was under the repulsion genetic architecture.

Inline graphic — The simulation results for case-control data with varying prevalence (K) and number of QTLs. The x axis quantifies the genetic architecture for the base population, in which the cases and the controls are sampled. The y axis represents the heritability on the liability scale. The x axis reflects the genetic architecture: negative/positive LD indicates the repulsion/coupling genetic architecture; LD=0 indicates the neutral genetic architecture. Of note, when , it was under the repulsion genetic architecture.