Table 1.
Baseline Characteristics of 3444 Participants Stratified by the APOE ε4 Allele Status
| All participants Mean (SD) N=3444 |
No copies of ε4 Mean (SD) N=2288 |
≥1 copy of ε4 Mean (SD) N=1156 |
p-value1 | |
|---|---|---|---|---|
| Age (years) | 71.9 (6.2) | 72.2 (6.4) | 71.3 (5.7) | <0.0001 |
| Education (years) | 12.6 (3.4) | 12.6 (3.4) | 12.7 (3.4) | 0.51 |
| Cognitive function (sd units) | 0.368 (0.658) | 0.390 (0.638) | 0.325 (0.694) | 0.006 |
| Body mass index (kg/m2) | 28.3 (6.0) | 28.2 (5.9) | 28.5 (6.0) | 0.27 |
| Systolic BP (mm Hg) | 138.1 (18.8) | 138.1 (18.9) | 138.1 (18.6) | 0.98 |
| Diastolic BP (mm Hg) | 78.0 (10.8) | 77.8 (10.4) | 78.4 (11.5) | 0.13 |
| Physical activity (hrs/week) | 3.1 (5.1) | 3.3 (5.4) | 2.9 (4.6) | 0.22 |
| Alcohol consumption (gms/week) |
0.45 (1.15) | 0.46 (1.16) | 0.43 (1.12) | 0.36 |
| Age at stroke (years) | 80.6 (7.3) | 81.1 (7.4) | 79.9 (7.0) | 0.10 |
| Age at death (years) | 85.7 (6.8) | 86.2 (7.0) | 84.6 (6.5) | <0.0001 |
| Females, % | 2101, 61% | 1424, 62% | 677, 59% | 0.03 |
| African Americans, % | 2269, 66% | 1429, 62% | 840, 73% | <0.0001 |
| Heart disease, % | 367, 11% | 257, 11% | 110, 10% | 0.12 |
| Diabetes, % | 221, 6% | 152, 7% | 69, 6% | 0.44 |
| Stroke, % | 505, 15% | 341, 15% | 164, 14% | 0.60 |
| Former smoker, % | 1327, 38% | 864, 38% | 463, 40% | 0.20 |
| Current smoker, % | 456, 13% | 301, 13% | 155, 13% | 0.84 |
| Deceased, % | 1457, 42% | 973, 43% | 484, 42% | 0.69 |
1
p-values are based on two-sample independent t-tests for continuous measures and chi-square test statistic for categorical measures comparing participants with no copies to ≥1 copy of ε4 allele