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Competition of rabbit MAbs with CD4Ig, VRC01 and 17b
| MAbs | Competitors
|
|||
|---|---|---|---|---|
| CD4Ig | VRC01 | 17b | ||
| Rabbit MAbs | 25-11 | ++ | +++ | − |
| 30-9 | ++ | +++ | − | |
| 41-7 | ++ | ++ | − | |
| 46-1 | ++ | +++ | − | |
| 57-5 | ++ | ++ | − | |
| 58-2 | ++ | ++ | − | |
| 78-4 | ++ | +++ | − | |
|
| ||||
| CD4bs MAbs | VRC01 | +++ | +++ | Enhance* |
| b12 | +++ | +++ | + | |
| F105 | +++ | +++ | +++ | |
| GE125 | +++ | +++ | ++ | |
| GE136 | +++ | +++ | ++ | |
| GE140 | +++ | +++ | ++ | |
|
| ||||
| V3 MAb | 447 | − | − | − |
+++, 75–100% competition; ++, 50–75% competition; +, 25–50 competition; −, < 25% competiti on.
17b enhanced VRC01 binding more than 30%.
