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Downregulation of STAT3-regulated genes via inhibition of STAT3 by LLL12 and FLLL32. ALDH+ and CD44+/CD24+ subpopulations were separated from Panc-1 and HPAC pancreatic cancer cells by flow cytometry. ALDH+ and CD44+/CD24+ subpopulations of Panc-1 and HPAC pancreatic cancer cells were treated with LLL12 (5 μM), FLLL32 (5 μM), or DMSO for 24 h. RNA was collected and gene expression was detected by RT-PCR.
