Table 4.

Hemodynamic effects of intravenously applied ivabradine in patients with advanced heart failure

Variable	Baseline	1 h	4 h	24 h	p
HR	93 ± 8	81 ± 7	68 ± 9	82 ± 11	<0.01
CI	2.2 ± 0.6	2.3 ± 0.5	2.5 ± 0.5	2.5 ± 0.5	0.149
SV	44 ± 11	51 ± 12	66 ± 17	53 ± 12	< 0.01
LVSW	39 ± 13	43 ± 14	58 ± 20	45 ± 17	< 0.01
RVSW	12 ± 5	13 ± 7	17 ± 9	14 ± 8	< 0.01
SAP	103 ± 7	101 ± 9	103 ± 12	100 ± 11	0.848
DAP	71 ± 6	65 ± 4	64 ± 10	63 ± 6	< 0.01
MAP	82 ± 6	78 ± 6	77 ± 11	76 ± 9	0.098
PASP	36 ± 11	37 ± 11	44 ± 15	40 ± 13	< 0.01
PADP	21 ± 7	20 ± 7	20 ± 8	20 ± 8	0.92
PAMP	27 ± 8	27 ± 8	29 ± 10	29 ± 9	0.18
PAWP	19 ± 4	18 ± 5	18 ± 5	18 ± 6	0.8
RAP	7 ± 5	8 ± 6	9 ± 5	9 ± 5	< 0.01
SVR	1,576 ± 374	1,426 ± 334	1,334 ± 420	1,340 ± 381	0.176
TPVR	571 ± 222	539 ± 195	566 ± 297	548 ± 195	0.663

Note: The p values are for the prespecified contrasts between baseline and 3, 4, 6, 8, and 24 h of Table 2 of De Ferrari GM, Mazzuero A, Agnesina L, et al. Favourable effects of heart rate reduction with intravenous administration of ivabradine in patients with advanced heart failure. Eur J Heart Fail. 2008;10(6):550–555.⁵⁷

Abbreviations: CI, cardiac index (L ×min⁻¹×m⁻²); DAP, diastolic arterial pressure (mm Hg); HR, heart rate (min⁻¹); LVSW, left ventricular systolic work (g); MAP, mean arterial pressure (mm Hg); PADP, pulmonary arterial diastolic pressure (mm Hg); PAMP, pulmonary arterial mean pressure (mm Hg); PASP, pulmonary arterial systolic pressure (mm Hg); PAWP, pulmonary artery wedge pressure (mm Hg); RAP, right atrial pressure (mm Hg); RVSW, right ventricular systolic work (g); SAP, systolic arterial pressure (mm Hg); SV, stroke volume (mL); SVR, systemic vascular resistance (dyn×s×cm⁻⁵); TPVR, total pulmonary vascular resistance (dyn×s×cm⁻⁵); h, hours.