Table 5.
Effect of curcumin on glucose insulin homeostasis of gliclazide in diabetic rats (n=6)
| Parameter | Insulin (µIU/mL)
|
Insulin resistancea
|
β-cell functiona
|
|||
|---|---|---|---|---|---|---|
| 2 h | 8 h | 2 h | 8 h | 2 h | 8 h | |
| Gliclazide | 14.13±0.32 | 12.58±0.75 | 89.78±1.67 | 83.14±5.74 | 202.68±7.61 | 173.29±9.67 |
| Curcumin | 7.21±0.29 | 6.86±0.31 | 82.41±4.84 | 76.87±3.33 | 56.82±1.76 | 55.19±2.76 |
| Gliclazide + curcumin (SDT) | 14.31±0.51 | 12.32±0.71 | 97.43±3.81 | 85.98±5.15 | 191.26±6.73 | 160.64±10.14 |
| Gliclazide + Ccrcumin (MDT) | 14.26±0.42 | 13.41±0.49 | 94.44±4.76 | 90.05±3.32 | 195.99±4.92 | 181.66±8.46 |
Notes: Data expressed as mean ± SD.
a
Calculated by homeostasis model assessment.
Abbreviations: MDT, multiple-dose treatment; SD, standard deviation; SDT, single-dose treatment.