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. Author manuscript; available in PMC: 2016 Nov 21.
Published in final edited form as: Clin Cancer Res. 2016 Jan 5;22(10):2359–2367. doi: 10.1158/1078-0432.CCR-15-2476

Table 2. Hematologic and non-hematologic toxicities (n = 574 patient-courses).

Grade 3 Grade 4


Toxicity Patients (%) Patient-courses (%) Patients (%) Patient-courses (%)
Hematologic
 Neutropenia 10 (29%) 75 (13%) 18 (53%) 29 (5%)
 Anemia 2 (6%) 3 (0.5%) 0 0
 Thrombocytopenia 4 (12%) 9 (1.6%) 2 (6%) 2 (0.3%)
Non-hematologic Patients (%) Episodes Patients (%) Episodes

Infections
 Pneumonia 8 (24%) 11 0 0
 Fever 3 (9%) 3 0 0
 Neutropenic fever 3 (9%) 3 0 0
 Bacteremia 1 (3%) 1 1 (3%) 1
 Cellulitis 2 (6%) 2 0 0
 Toxoplasmosis 1 (3%) 1 0 0
 Parotitis 1 (3%) 1 0 0
 Appendicitis 1 (3%) 1 0 0

Other toxicities
 VTE 2 (6%) 2 1 (3%) 1
 Dehydration 1 (3%) 1 0 0
 Fatigue 1 (3%) 1 0 0
 CHF exacerbation 1 (3%) 1 0 0
 Atrial fibrillation 1 (3%) 0 0 0

Abbreviation: CHF, congestive heart failure.